Recent studies have identified multipotent cells in the adult human brain whose progeny express glial or neuronal markers. The possibility to isolate and then propagate neural stem cells (NSCs), and their potential applications in cell therapy have attracted a lot of research interest in recent years.
Many aspects related to the basic biological properties of NSCs, and their possible application as a therapeutic tool still have to be stablished.
Acquisition of voltage-gated ionic channels is a crucial part of terminal differentiation, as such channels are required for excitability and play a fundamental role in morphological and functional maturation of individual neurons and neural networks.
Some previous group results
*P. Vaca, *F. Martín, J.M. Vegara-Meseguer, J.M. Rovira, G. Berná, B. Soria (2006) “Induction of differentiation of ES cells into islet cells by Fetal Soluble Factors”. Stem Cells, 24: 258-265.
J.M. Vegara-Meseguer, B. Soria, (2005) “Ion channels in the plasma membrane of mouse embryonic stem cells and their physiological role”.Journal of Physiology and Biochemistry, 61, 1.
B. Soria, T. León-Quinto, J. Jones, P. Sepulcre, J.M. Vegara-Meseguer, P. Vaca, G. Berná, E. Roche, J.A. Reig, F. Martín, (2002) “Estrategias para la obtención de células productoras de insulina a partir de células madre”, Fundación Valenciana de Estudios Avanzados. Generalitat Valenciana. Conselleria de Sanitat.