Alfonso Pérez Garrido, PhD
Associate Professor · Chemistry · UCAM Universidad Católica de Murcia
QSAR modeller and chemist with three recognized six-year research periods, working on the rational design of new drugs and the prediction of toxicity, mutagenicity and bioactivity of small molecules.
About
Alfonso obtained his degree in Chemical Sciences from the University of Murcia in 1996 with an outstanding average mark, and his PhD in Environmental Engineering and Toxicology from UCAM in 2010, awarded with the highest distinction (Sobresaliente Cum Laude). He joined UCAM permanently in 2011 as a Contratado Doctor and has held the rank of Associate Professor since 2019.
His research focuses on the development of QSAR (Quantitative Structure-Activity Relationship) models applied to mutagenicity, toxicity and the rational design of new drugs. His scientific track record has been formally recognized with three consecutive six-year research periods (sexenios) by the Spanish CNEAI, covering 2006-2011, 2012-2017 and 2018-2023.
Collective output includes 16 publications in Q1 journals, 2 in the top decile (D1), an H-index of 15 and 791 citations on SCOPUS. He is also co-inventor on several technology-transfer outputs from the BIO-HPC group, including patents covering Kukoamine A, Zeaxanthin and Clexane as broad-spectrum antiviral candidates.
Research focus
QSAR & toxicity prediction
Development of quantitative structure-activity relationship models for mutagenicity, toxicity and ADME-Tox prediction of small molecules.
Rational drug design
Application of structure- and ligand-based methods to design selective inhibitors, including acetylcholinesterase and viral targets.
Bioactives & natural compounds
Identification of bioactive natural compounds from plant sources with applications in diabetes, infection control and mosquito repellency.
Selected publications
- Monastrol suppresses invasion and metastasis in human colorectal cancer cells by targeting fascin independent of kinesin-Eg5 pathway.
- 2D fingerprinting and molecular docking studies identified potent mosquito repellents targeting odorant binding protein 1.
- Fishing the Targets of Bioactive Compounds from Psidium guajava L. Leaves in the Context of Diabetes.
- Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors.
- Combined Structure and Ligand-Based Design of Selective Acetylcholinesterase Inhibitors.