Josefina María Vegara Meseguer

Josefina María Vegara Meseguer, PhD

Associate Professor · Escuela Politécnica Superior · UCAM Universidad Católica de Murcia

Bioengineer and biophysicist working at the interface of medical biophysics, regenerative medicine and computational chemistry for drug discovery.

About

Josefina holds a PhD in Bioengineering from Universidad Miguel Hernández de Elche (2005), an MSc in Bioengineering (UMH, 2000) and a degree in Physical Sciences from Universitat de València (1998). She joined UCAM in 2006 as a Profesor Contratado Doctor (PDI) at the Escuela Politécnica Superior, where she has built a research line on medical biophysics and computational drug discovery.

Her research has covered the reconstruction of endocrine pancreatic function, the electrophysiological characterisation of insulin-producing cells derived from stem cells, and the clinical application of infrared thermography for the follow-up of muscular dystrophies. Earlier in her career she was a postdoctoral researcher at the Faculty of Medicine, Lund University Hospital (Sweden), and worked with the Wallenberg Neuroscience Center and the CABIMER stem-cell centre.

Within BIO-HPC, she contributes to the computational chemistry track — co-author on the group’s antiviral repurposing work (Kukoamine A, Zeaxanthin, Clexane as furin inhibitors) and co-inventor on related Spanish patents. She has been an invited speaker at the Max Planck Institute and at multiple international forums on bioengineering and rare diseases.

Focus areas

Medical biophysics

Electrophysiology of insulin-producing cells, regenerative medicine and clinical infrared thermography for rare diseases.

Bioengineering

Reconstruction of pancreatic endocrine function and characterisation of stem-cell-derived models.

Computational drug discovery

Co-author on the BIO-HPC antiviral programme — identification of natural compounds as furin inhibitors against coronavirus.

Selected publications

  • Identification of Kukoamine A, Zeaxanthin, and Clexane as new furin inhibitors. Zaragoza-Huesca D, Martínez Cortés C, Banegas Luna AJ, et al, Vegara Meseguer JM. International Journal of Molecular Sciences, MDPI, 23(5):2796–2812, 2022. 10.3390/ijms23052796
  • Relationship between infrared skin radiation and functional tests in patients affected by Emery-Dreifuss muscular dystrophy: Part 2. Cabizosu A, Berenguer Vidal R, Vegara Meseguer JM, Martínez Almagro Andreo A, Maiquez Mojica V, Casu G, Carboni N. Medical Hypotheses, Elsevier, 146:348–353, 2021.
  • Relationship between infrared skin radiation and muscular strength tests in patients affected by Emery-Dreifuss muscular dystrophy. Cabizosu A, Carboni N, Martínez Almagro Andreo A, Casu G, Sánchez CR, Vegara Meseguer JM. Medical Hypotheses, Elsevier, 138:109592, 2020.

Patents

  • Zeaxanthin for the prevention and treatment of viral infection, preferably by coronavirus. Spanish patent ES2899697, granted 29 September 2022.
  • Kukoamine A for the prevention and treatment of viral infection, preferably by coronavirus. Spanish patent ES2899548, granted 20 September 2022.